hrp0092s11.2 | Recent Advances in our Understanding of Hypogonadotrophic Hypogonadism | ESPE2019

Novel Insights into the Regulation of Reproduction Using 3D-Imaging in Transparent Fetuses and Postnatal Animals

Giacobini Paolo

GnRH–secreting neurons are unusual neuroendocrine cells, as they originate in the nasal placode outside the central nervous system during embryonic development, and migrate to the hypothalamus along the vomeronasal and terminal nerves. Postnatally these cells become integral members of the hypothalamic-pituitary-gonadal axis and they regulate puberty onset and reproduction through the release of GnRH into the pituitary portal blood vessels for delivery to the anterior pit...