hrp0084p2-577 | Thyroid | ESPE2015

Osteoprotegerin and fT4 Levels in Subclinical Hypothyroidism of Childhood

Giannakopoulos Aristeidis , Katsantoni Elena , Efthymiadou Alexandra , Kritikou Dimitra , Chrysis Dionisios

Background: Osteoprotegerin (OPG) is a cytokine of the tumour necrosis factor receptor family, expressed in various cells types of the body including osteoblasts and endothelial cells. It acts as a soluble decoy receptor of RANK ligand preventing stimulation of osteoclastogenesis. In adults, subclinical hypothyroidism (SH) has been associated with cardiovascular complications. Furthermore several studies have linked OPG levels to increased cardiovascular risk.<p class="abs...

hrp0082p3-d1-976 | Thyroid | ESPE2014

Adiposity and Pubertal Status Effects on Thyroid Function in Overweight Children and Adolescents

Giannakopoulos Aristeidis , Pervanidou Panagiota , Lazopoulou Natalia , Chrousos George , Kanaka-Gantenbein Christina

Background: In recent years, studies have consistently demonstrated higher TSH concentrations in overweight/obese children and adults compared with normal weight individuals, whereas the levels of thyroid hormones in peripheral blood remain within normal range. This euthyroid hyperthyrotropinemia on the background of a worldwide increase in childhood obesity raises the question of whether subjects with this elevated TSH should be treated.Objective and hy...