hrp0098p1-183 | Pituitary, Neuroendocrinology and Puberty 3 | ESPE2024

Arginine-stimulated copeptin for Central Diabetes Insipidus diagnosis in children.

Napoli Flavia , Casalini Emilio , Pisati Angelica , Balsamo Mirna , Camia Tiziana , Bianchin Silvia , Zucconi Alice , Spacco Giordano , Simiele Giulia , Marcenaro Silvia , Fava Daniela , Elsa Maria Allegri Anna , Angelelli Alessia , Patti Giuseppa , Di Iorgi Natascia , Maghnie Mohamad

Introduction: Central diabetes insipidus (CDI) diagnosis is challenging, since water deprivation test has sub-optimal sensitivity and specificity and carries an important burden for patients and care-givers. Several authors have investigated arginine as a stimulus for AVP secretion – evaluated by dosing copeptin, a pre-pro AVP cleavage product - and normal values for adult patients have already been established.Aims and Met...