hrp0082p2-d1-294 | Bone | ESPE2014

Determinants of Vitamin D Levels in Children and Adolescents with Down Syndrome

Stagi Stefano , Lapi Elisabetta , Scalini Perla , Greco Paolo Del , Ricci Franco , Marino Achille , de Martino Maurizio , Seminara Salvatore

Background: Down syndrome (DS) is the most common genetic (chromosomal) mental retardation syndrome. In these patients, several environmental and hormonal factors contribute to low bone mineral density (BMD), among these factors, vitamin D may play a significant role in the health of patients with DS. However, poor studies have evaluated 25-hydroxy cholecalciferol (25(OH)D) levels in DS.Objective and hypotheses: The purpose of this study was to assess se...

hrp0082p3-d1-935 | Puberty and Neuroendocrinology | ESPE2014

An Unusual Case of Early and Accelerated Puberty

Scalini Perla , Stagi Stefano , Pelosi Paola , Ricci Franco , Anzillotti Giulia , Greco Paolo Del , Seminara Salvatore , de Martino Maurizio

Background: Unlike precocious puberty, early and/or fast puberty have been less studied, despite the fact that this disorder may be associated to an organic lesion at CNS level.Objective and hypotheses: We illustrate a case of early and fast puberty in a girl with an occult intra-cranial tumor.Method: The girl was the first child of non-consanguineous, Italian parents. The family had a positive history of early puberty. Target heig...