hrp0084p2-262 | Diabetes | ESPE2015

Factitious Administration of Analogue Insulin to a 2-Years-Old Child

Thanawala Nehal , Cheney Sarah , Wark Gwen , Thevis Mario , Thomas A , Tziaferi V , Greening James

Background: Hypoglycaemia precipitated by factitious insulin administration presents in a very similar way to hypoglycaemia caused by hyperinsulinism. It is difficult to ascertain clinically if the hypoglycaemia is secondary to exogenous administration or endogenous insulin secretion. Diagnosis is based on circumstantial evidence and biochemical tests which include insulin and C-peptide level.Objective and hypotheses: We would like to report a case of a ...

hrp0084p3-711 | Diabetes | ESPE2015

Heterogeneous Presentation of Paediatric Hyperglycaemic Hyperosmolar State – A Case Series

Mohamed Zainaba , Randell Tabitha , Sundaram Prem , Greening James , Denvir Louise , Sachdev Pooja

Background: The hyperosmolar hyperglycaemic state (HHS) is rare, but recognised, life-threatening clinical entity in children with type 2 diabetes (T2DM). It is also reported as presenting feature in other types of diabetes and metabolic disorders. The estimated mortality in HHS is 10–20%, ten times higher than Diabetic Ketoacidosis (DKA).The mainstay of management involves aggressive fluid therapy with insulin and managing complications namely; rhabdomyolysis, multi-orga...

hrp0089rfc10.1 | Late Breaking | ESPE2018

Patients with GH Insensitivity and IGF-1 Resistance Harbour Copy Number Variants Causing a Silver-Russell-Like Phenotype

Cottrell Emily , Chatterjee Sumana , Moore Gudrun , Ishida Miho , Greening James , Wright Neil , Bossowski Artur , Deeb Asma , Al Basiri Iman , Rose Steven , Mason Avril , Ahn Joowook , Bint Susan , Savage Martin , Metherell Louise A , Storr Helen L

Introduction: Our Centre is an international referral centre for genetic analysis of children with short stature (SS) and features of GH/IGF-1 resistance. Following candidate gene and whole exome sequencing, diagnoses for ~50% patients remained elusive. Copy number variation (CNV) has not previously been investigated in GH/IGF-1 resistance and we hypothesised that CNVs contribute to the phenotype in our undiagnosed cohort.Experimental Design and Methodol...