hrp0086p1-p756 | Pituitary and Neuroendocrinology P1 | ESPE2016

β-hCG from an Occult Source Causing Peripheral Precocious Puberty: Identification of the Tumour 6 Years After Presentation

Ekberzade Azad , Abali Saygin , Atay Zeynep , Bas Serpil , Gurbanov Ziya , Turan Serap , Guran Tulay , Bereket Abdullah

Background: β-hCG secreting germ-cell tumors (β-hCG-ST) are rare causes of Peripheral precocious puberty (PPP) in boys and usually located in intracranial region. Liver, retroperitoneum, testis and mediastinal cavity are the other localizations reflecting embryonic germ cell sites.Objective and hypotheses: We present a patient with PPP due to elevated β-hCG levels, but extensive efforts to find the source of elevated β-hCG was unrevea...

hrp0084p2-274 | Diabetes | ESPE2015

Friedreich’s Ataxia Presenting with Diabetes Mellitus in an Adolescent

Bas Serpil , Abali Saygin , Atay Zeynep , Gurbanov Ziya , Turkdogan Dilsad , Turan Serap , Bereket Abdullah

Background: Friedreich’s ataxia (FA) is an autosomal recessive neurodegenerative disorder characterised by progressive ataxia with limb muscle weakness, absent lower limb reflexes, extensor plantar responses, dysarthria, decreased vibratory sense and proprioception. The most common molecular abnormality is a GAA trinucleotide repeat expansion in intron 1 of the frataxin (FXN) gene. Patients with FA are at risk of getting increased blood sugar levels, or ...

hrp0084p2-559 | Thyroid | ESPE2015

Central or Primary Hypothyroidism? How to Differentiate in Patients with Low T4 but Mildly Elevated TSH Levels

Turan Serap , Gurbanov Ziya , Bas Serpil , Abali Saygin , Atay Zeynep , Bereket Abdullah

Background: Central hypothyroidism (CH) is caused by TSH and/or TRH deficiency leading to hypothyroxinemia with low, normal or mildly elevated TSH levels. Differentiation of CH with mildly elevated TSH levels from primary hypothyroidism (PH) can be difficult. However, this differentiation has important clinical implications (i.e. cortisol replacement before L-thyroxine).Objective and hypotheses: In this study, we constructed a nomogram all...

hrp0084p3-975 | GH & IGF | ESPE2015

Factors Effecting Response to Growth Hormone Treatment in Children with Turner Syndrome

Bas Serpil , Abali Saygin , Atay Zeynep , Haliloglu Belma , Gurbanov Ziya , Guran Tulay , Bereket Abdullah , Turan Serap

Background: Short stature is the most common presenting symptom in Turner Syndrome (TS). GH treatment helps alleviating short stature in TS, although response to treatment varies significantly.Objective and hypotheses: We aimed to evaluate the response to GH treatment and factors affecting this response in children with TS.Method: Forty-nine patients with TS diagnosed by cytogenetic analysis and who had been followed minimum of 1-y...

hrp0086p2-p305 | Diabetes P2 | ESPE2016

Thiamine Responsive Megaloblastic Anemia Due to SLCA19A2 Gene Mutation: Another Cause of Neonatal Diabetes with Succcesfull Switch from Insulin to Thiamine

Bas Serpil , Akbarzade Azad , Atay Zeynep , Gurbanov Ziya , Guran Tulay , Turan Serap , Franco Elisa De , Ellard Sian , Bereket Abdullah

Itroduction: Thiamine responsive anemia (TRMA) known as Rogers syndrome; is an early-onset, autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness. Diabetes in this condition is well described in infancy but has only very rarely been reported in association with neonatal diabetes.Case: 3-months old male patient with neonatal diabetes was admitted to our outpatient clinic because of uncontrolled hy...

hrp0086p1-p813 | Syndromes: Mechanisms and Management P1 | ESPE2016

Reconsideration of Mid-Parental Height Calculation

Bereket Abdullah , Bugur Ibrahin Sinan , Guran Tulay , Atay Zeynep , Ekberzade Azad , Gurbanov Ziya , Oge Ece , Tas Cektar Seyid Riza , Turan Serap , Furman Andrzej

Background: Estimation of the child’s genetic height potential (target height) is an important tool in evaluating growth disorders. Midparental height (MPH) calculated as (Mothers height+Fathers height)/2±6.5 cm), used for this purpose, represents the child’s expected height based on parental heights.Objective and hypotheses: To evaluate the classical MPH calculations for our population and to explore the optimal MPH model using different ...