hrp0086fc9.5 | Pathophysiology of Disorders of Insulin Secretion | ESPE2016
Willemsen Ruben
, Burling Keith
, Ackland Fran
, Edge Julie
, Diaz Renuka
, Barker Peter
, Guy Catherine
, Dunger David
Background: The majority of drug developments in type 1 diabetes (T1D) are aimed at preventing decline of beta cell function (BCF), as this has been associated with better glycaemic control and fewer long-term complications. Traditionally, BCF is evaluated by the C-peptide response to the labour-intensive mixed-meal-tolerance-test (MMTT), but theres a need for a more practical alternative. We developed a new method to measure C-peptide in dried blood spots (D...