hrp0095p1-497 | GH and IGFs | ESPE2022

Metabolomics profile of children with growth hormone deficiency

Shilo Smadar , Bar Noam , Halloun Rana , Cohen Michal , Rossman Hagai , Gal Shoshana , Oren Meirav , Malitsky Sergey , Itkin Maxim , Shahaf Nir , Lotan-Pompan Maya , Godneva Anastasia , Weinberger Adina , Tiosano Dov , Segal Eran

Background and Objectives: In recent years, a growing number of studies investigated the profile of serum metabolomics in health and disease. These studies have led to the discovery of novel biological biomarkers and causative agents for a variety of medical conditions. Here, we focused on profiling serum metabolites of children diagnosed with growth hormone deficiency (GHD).Methods: We conducted a prospective study and ...

hrp0094fc10.2 | Thyroid | ESPE2021

Prevalence and outcome of Congenital Central Hypothyroidism: A Multicenter Study

Lucie Levaillant , German , Almashanu , De Vries Liat , Gil Merav , Halloun Rana , Haim Alon , Eyal Ori , Magid Yael , Levi Floris , Pivko-Levi Dikla , Nir Judith , Pinhas-Hamiel Orit , Tenenbaum-Rakover Yardena , Natacha Bouhours-Nouet , Frederic Illouz , Nathalie Bouzamondo , Patrice Rodien , Delphine Prunier-Mirebeau , Regis Coutant

Background: More than half of newborns with central congenital hypothyroidism (C-CH) have moderate-to-severe hypothyroidism in the neonatal phase, requiring immediate thyroxine therapy to prevent brain damage. The Israeli newborn screening for CH is based on the measurement of total T4 (TT4) followed by TSH measurement. However, when TSH is within the normal range the physicians are not informed of the results and therefore the diagnosis of C-CH and initiation...