hrp0095p1-161 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Causal Effect of Age at Menarche on the Risk for Depression: Results from a Two-Sample Multivariable Mendelian Randomization Study

Hirtz Raphael , Hars Christine , Naaresh Roaa , Hergen Laabs Björn , Antel Jochen , Grasemann Corinna , Hinney Anke , Hebebrand Johannes , Peters Triinu

Background: A fair number of epidemiological studies suggest that age at menarche (AAM) is associated with depression, but the reported effect sizes are small, and there is evidence of residual confounding. Moreover, previous Mendelian randomization (MR) studies to avoid inferential problems inherent to epidemiological studies have provided mixed findings.Methods: To clarify the causal relationship between age at menarch...