hrp0098p2-393 | Late Breaking | ESPE2024

Transcriptomic analysis of peripheral blood mononuclear cells reveals immune and metabolic pathways associated with both puberty-blockade and gender-affirming sex hormone therapy in young transgender individuals

Cross Heather , Peckham Hannah , Peng Junjie , Radziszewska Ania , Butler Gary , Jury Elizabeth , Rosser Elizabeth , A Robinson George , Ciurtin Coziana

Introduction: Sex differences associated with inflammation have been observed across numerous autoimmune and cardiometabolic conditions. We aim ed to explore the differential impact of sex hormones/sex chromosomes on molecular pathways potentially relevant for immune cell functions using a unique post-pubertal transgender cohort.Methods: RNA-sequencing was performed on peripheral blood mononuclear cells (PBMCs) from a he...