hrp0082p2-d3-503 | Perinatal and Neonatal Endocrinology | ESPE2014

Survey of Opinion on the Antenatal and Surgical Management of Disorders of Sex Development and Congenital Adrenal Hyperplasia

White Mary , Hewitt Jacqueline

Background: Congenital adrenal hyperplasia (CAH) is characterised by elevated adrenal androgens which can lead to virilisation of affected females.Objective and hypotheses: To outline clinical opinion on two controversial aspects of CAH management (antenatal dexamethasone and genital surgery of affected females) which was hypothesised would differ between regional centres.Methods: A survey was conducted via the Aus...

hrp0092p1-124 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

A Human Model Showing the Ability of Testis XX Cells to Masculinise into Sertoli Cells and Success of Microtese Surgery in Paediatric Azoospermia

Atlas Gabby , Rombauts Luk , Wall Meaghan , MacGregor Duncan , Lall Paula , Harley Vincent , Hewitt Jacqueline

In the typical developing gonad, cells with XY chromosomes become masculinised into Sertoli cells, leading to the development of the bipotential gonad into testes. Disruptions to sex determining genes and transcription factors, or XX chromosome complement, typically leads to failure of Sertoli cell development. In the study of sex determination, upregulation of specific genes in animal models has sucessfully led to male factor expression in XX cells in some animals but not in ...