hrp0092p2-41 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

A Clinical Dilemma in the Detection of Paediatric Hypophosphataemia

Ho Clement K.M. , Tan Jun Guan

Background: In paediatric patients with metabolic bone diseases, measurement of the concentrations of minerals including inorganic phosphate is often indicated, and hypophosphataemia is a clinically manageable biochemical disorder. The clinical interpretation of plasma or serum phosphate concentrations depends, to a certain extent, on the age- and gender-specific reference intervals applicable to the laboratory methods employed.Whereas h...

hrp0092p1-67 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) | ESPE2019

Screening of Congenital Hypothyroidism using Umbilical Cord Blood in a Maternity Hospital

Ho Clement K.M. , Loh Siew Kee , Setoh Johnson W.S.

Background: Approximately one baby in 2000-3000 is born with congenital hypothyroidism (CHT). Newborn screening of CHT is conducted in different countries by the measurement of either thyroid stimulating hormone (TSH) of free thyroxine (FT4) or both. Whereas most Western countries screened CHT by using a blood spot collected on day 3 to 5 of life, some countries' programmes measure umbilical cord blood TSH or FT4 for the screening of CHT. In our maternity ...