hrp0082p1-d2-40 | Bone | ESPE2014

Effects and Limitations of Cinacalcet Therapy in Neonatal Severe Hyperparathyroidism

Doehnert Ulla , Goepel Wolfgang , Hoeppner Wolfgang , Hiort Olaf

Background: Neonatal severe hyperparathyroidism (NSHPT) has been associated with inactivating mutations of the calcium-sensing receptor (CASR) gene. Impaired inhibition of PTH secretion by extracellular ionized calcium and decreased urinary excretion of calcium leads to severe hypercalcemia in the first days of life. Calcium responsiveness of the CaSR is amplified by type 2 calcimimetic agents like cinacalcet, which has been able to normalize PTH and calcium levels in cases of...

hrp0092t7 | Top 20 Poster | ESPE2019

Establishing of a Novel NGS Tool for the Diagnosis of X-linked Hypophosphatemia (XLH)

Thiele Susanne , Stubbe Anita , Werner Ralf , Hiort Olaf , Hoeppner Wolfgang

X-linked hypophosphatemia (XLH) is the most common genetic disorder of phosphate homeostasis. It is caused by inactivating mutations in the PHEX gene, which encodes a phosphate regulating endopeptidase predominantly expressed in osteoblasts, osteocytes, and odontoblasts.In children there is a broad phenotypic spectrum of XLH ranging from isolated hypophosphatemia without clinical signs up to severe symptoms, such as rickets, extreme lower limb d...