hrp0092p2-220 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Normalized Pubertal Tempo of Maturation and Pubertal Height Gain in Girls with MPHD, Using a Physiological Treatment Approach with Natural Estrogens & rhGH

Lundberg Elena , Kriström Berit , Holmlund Mariell , Albertsson-Wikland Kerstin

Background: Pubertal tempo of breast development on natural sex-steroid replacement therapy in girls with multiple pituitary hormone deficiencies (MPHD) and pubertal growth spurts on adequate GH-treatment regimens were unknown in 1989 and are still not known.Objective and Hypotheses: A hypothesis driven prototype trial1,2 was initiated in the late 80ies aiming to mimic normal puberty regarding both pubertal ma...