hrp0098p2-315 | Late Breaking | ESPE2024

Semaglutide modulated the gut microbiome composition and improved bile acid profiles in a mouse model of diabetic nephropathy

Kang Huimin , Chen Ruimin

Background: Semaglutide is a glucagon-like peptide-1 receptor agonist which has been confirmed that it offered kidney-protective effects in patients with type 2 diabetes and chronic kidney disease. However, the exact mechanism by which Semaglutide exerts its reno-protection remains largely unknown.Purpose: This study aim ed to investigate whether Semaglutide has beneficial effects in diabetic nephropathy mice via the gut...