hrp0092p3-196 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Precocious Pseudo-Puberty Presenting with Bilateral Ovarian Involvement and Progressing to Juvenile Granulosa Cell Tumor in a 2-Year-Old Girl

Barakizou Hager , Donaldson Malcolm , Huma Zilla , Amary Fernanda , Gannouni Souha

Background: Feminising preocious pseudo-puberty in McCune Albright syndrome (MAS) and juvenile granulosa cell tumour (JGCT) arises from bilateral and unilateral estradiol hypersecretion respectively. GNAS mutations have been described in some cases of JGCT as well causing MAS.Aim: To describe a case in which MAS was evoked initially, but then progressed to JGCTCase: A girl aged 2 y...