hrp0086p2-p780 | Pituitary and Neuroendocrinology P2 | ESPE2016

Precocious Puberty: A Single Academic Center Experience

Huttunen Heta , Varimo Tero , Miettinen Paivi , Hero Matti , Raivio Taneli

Background: The frequency of makorin RING-finger protein 3 gene (MKRN3) mutations in Finnish patients with precocious puberty (PP) is not known. As a first step to investigate this, we describe the diagnoses underlying PP in a single academic center.Objective and hypotheses: To review the diagnoses in children who were presented with signs of PP (adrenarche excluded) at the Helsinki University Hospital, with a special emphasis on the identification of fa...

hrp0094p1-186 | Pituitary B | ESPE2021

Additive effect of androgens and estrogens on pubertal growth acceleration

Huttunen Heta , Varimo Tero , Huopio Hanna , Voutilainen Raimo , Tenhola Sirpa , Miettinen Paivi , Raivio Taneli , Hero Matti ,

Objective: The influence of androgens and estrogens on growth is complex, and understanding their relative roles is important for optimizing the treatment of children with various disorders of growth and puberty.Design: We examined the proportional roles of androgens and estrogens in the regulation of pubertal growth in boys with constitutional delay of growth and puberty (CDGP). The study compared 6-month low-dose intramuscular testoste...

hrp0097p1-540 | Pituitary, Neuroendocrinology and Puberty | ESPE2023

Central precocious puberty in boys: clinical decision-making and secular trend

Huttunen Heta , Kärkinen Juho , Varimo Tero , J. Miettinen Päivi , Raivio Taneli , Hero Matti

Objective Recent studies suggest that boys are undergoing puberty at a younger age. Further, the number of idiopathic male central precocious puberty (CPP) cases are increasing over time. Only a few studies have evaluated the etiological factors in boys with CPP. We describe the etiology of CPP. Further, we define key auxological and clinical cues indicative of organic CPP (OCPP) and characterize the incidence of CPP.Methods&#x20...