hrp0089fc12.5 | Diabetes and Insulin 2 | ESPE2018

Effect of Homocysteine-Lowering Therapy on Diabetic Nephropathy in children and adolescents with Type 1 Diabetes

Elbarbary Nancy , Ismail Eman Abdel Rahman , Zaki Mamdouh Ahmed , Ibrahim Marwa Zaki , El-Hamamsy Manal

Background: Diabetic nephropathy (DN) is a major microvascular complica-tion of type 1 diabetes mellitus (T1DM). Homocysteine levels have been found elevated in T1DM patients with DN due to several causes, including dietary deficiencies of folic acid and B Vitamins. Hyperhomocysteinemia induces renal injury and is associated with increasing urinary albumin excretion in patients with diabetes. We therefore performed a randomized-controlled trial of oral supplem...