ESPE Abstracts

Context: Wolfram syndrome (WS) is an autosomal recessive neurodegenerative disorder caused by mutations in the WFS1 gene characterized by central diabetes insipidus, juvenile-onset diabetes mellitus (DM), optic atrophy (OA), and deafness. The natural history of WS is variable, even within the same family and with the same mutation.Objective: The aimof this study is to report the phenotypes of five patients of Dr...