hrp0098rfc14.5 | Fetal and Neonatal Endocrinology | ESPE2024

The utility of ketones in screening for congenital hyperinsulinism: a retrospective evaluation.

Whitehead Jennifer , Worth Chris , Beeston Helen , Hird Beverly , Banerjee Indraneel

Background: Congenital hyperinsulinism (HI) results in hyperinsulinemic hypoglycaemia in infants; a significant risk factor for brain injury due to neuroglycopenia and the suppression of alternative neuroprotective mechanisms such as ketogenesis. Neuronal damage can occur in both transient and persistent HI, with worse neurodevelopmental outcomes reported in those who receive a delayed diagnosis. There is currently no method for screening for HI and neuronal d...

hrp0095fc3.1 | Early Life and Multisystem Endocrinology | ESPE2022

HYPO-CHEAT: Personalised Technology Reduces Real-World Hypoglycaemia by 25%

Worth Chris , Nutter Paul , Salomon-Estebanez Maria , Auckburally Sameera , Banerjee Indraneel , Harper Simon

Background and Aims: Hypoglycaemia is a life-threatening risk for many patients and prevention is individualised and complex. Continuous Glucose Monitoring (CGM) shows promise but current accuracy is insufficient for acute hypoglycaemia detection and data review services are complex and generic. Machine Learning is increasingly used but ignores weekly hypoglycaemia patterns and behaviour change and thus has demonstrated no real-world reduction in hypoglycaemia...

hrp0095rfc3.1 | Early Life and Multisystem Endocrinology | ESPE2022

Brain Magnetic Resonance Imaging Changes in Childhood and its possible correlation with Unrecognised Early Life Hypoglycaemia

Ramya Gokul Pon , Banerjee Indraneel , Ramsden Katie , Worth Chris , Worthington Sarah , Salomon Estebanez Maria

Introduction: The neonatal threshold for hypoglycaemia is debatable and makes its treatment challenging. Neonatal hypoglycaemia can be transient and yet pose a significant risk of neuroglycopaenia, especially with severe and recurrent hypoglycaemia in Congenital Hyperinsulinism. Untreated hypoglycaemia induced cerebral injury can be identified by magnetic resonance (MR) brain scan changes affecting cerebral white matter, occipital lobes and posterior parietote...

hrp0095p1-209 | Adrenals and HPA Axis | ESPE2022

Systematic review of cortisol levels during acute illnesses in children and young people not known to have glucocorticoid deficiency

Banerjee Indraneel , Patel Leena , Fullwood Catherine , Hird Beverly , Chawla Meghna , Tetlow Lesley , Rezai Mohammad

Importance: Current practice of doubling or trebling the basal glucocorticoid (GC) replacement dose during acute illnesses in children and young people (CYP) with GC deficiency is extrapolated from research in adults and not based on robust evidence. Endogenous cortisol levels during acute illnesses in CYP without GC deficiency can provide insight for optimal GC stress dosing for CYP with GC deficiency.Objective: To summ...

hrp0095p1-493 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2022

Families' Experiences of Continuous Glucose Monitoring in The Management of Congenital Hyperinsulinism: A Thematic Analysis

Auckburally Sameera , Worth Chris , Salomon-Estebanez Maria , Nicholson Jacqueline , Harper Simon , W Nutter Paul , Banerjee Indraneel

Background and Aims: In patients with congenital hyperinsulinism (CHI), recurrent hypoglycaemia can lead to longstanding neurological impairments. At present, glycaemic monitoring is with infrequent fingerprick tests; a practice which can miss hypoglycaemic episodes between tests. Continuous glucose monitoring (CGM) is a promising alternative method which has the utility to identify risk and patterns of hypoglycaemia. Although CGM is well established in type 1...

hrp0094p2-125 | Diabetes and insulin | ESPE2021

Focal Congenital Hyperinsulinism in Infancy is Directly Linked to Increased Numbers of Islet Pancreatic Polypeptide Cells in Islets.

Banerjee Indraneel , Worth Chris , Salomon-Estebanez Maria , Yau Daphne , Jabbar Shamila , Hall Caroline , Dunne Mark ,

Congenital Hyperinsulinism (CHI) is primarily associated with defects in the regulated release of insulin from ß-cells but little information is available about the role of other islet cell types. Pancreatic polypeptide (PP) cells represent a minor component of the islet endocrine cell population. PP causes satiety, decreases gastrointestinal tract motility and suppresses glucagon release. Since CHI is associated with feeding problems and loss of glucagon-mediated counter...

hrp0097p1-293 | GH and IGFs | ESPE2023

Healthcare professionals’ perceptions on the quality and evolution of digital health devices to support paediatric growth hormone therapy: Results of a UK participatory study

Rivera-Romero Octavio , R Kapoor Ritika , Mathew Verghese , Tollerfield Sally , Shah Pratik , Banerjee Indraneel , Koledova Ekaterina

Background: Long-term treatment with recombinant human growth hormone (r-hGH) is often challenging for children and adolescents, their caregivers and healthcare professionals (HCPs), as treatment requires daily injections over several years. Connected digital health devices facilitate this by automating the injection process to improve comfort, reduce anxiety and collect GH treatment data so that accurate adherence information is available to HCPs in real-time...

hrp0097p1-502 | GH and IGFs | ESPE2023

Integration of Nurse-Led Virtual Reviews with Growth Hormone Device-Linked Adherence: a mixed methods, feasibility study

Stokes Helen , Jones Julie , Worth Chris , Nicholson Jaqueline , Fullwood Catherine , Banerjee Indraneel

Introduction: Easypod-connect™ for childhood growth disorders is a unique connected system that enables the transmission of injection adherence information for recombinant human growth hormone (r-hGH). Although this system has the potential to facilitate greater adherence, observational studies have shown declining adherence over prolonged periods when used without additional support. Supplemental nurse practitioner support has been envisaged but not inv...

hrp0098fc14.4 | Fetal and Neonatal Endocrinology | ESPE2024

Efficacy and Safety across Subgroups in Children with Congenital Hyperinsulinism Treated with Dasiglucagon

Banerjee Indraneel , S. Thornton Paul , Birch Sune , Boge Eva , Ivkovic Jelena , Gondolf Theis , D Leon Diva

Background: Congenital hyperinsulinism (CHI) is a rare disease affecting neonates, infants, and children caused by dysregulated insulin secretion resulting in severe recurrent hypoglycemia. Early treatment is necessary to limit the risk of neurologic and developmental sequelae. Dasiglucagon is a glucagon analog (stable liquid formulation) suitable for continuous subcutaneous infusion shown to raise blood glucose in a dose-dependent manner. Result...

hrp0098rfc14.6 | Fetal and Neonatal Endocrinology | ESPE2024

Utility of Continuous Glucose Monitoring in hospital monitoring of patients with Hyperinsulinism

De Silva Shamani , Worth Chris , Worthington Sarah , O'Shea Elaine , Salomon-Estebanez Maria , Banerjee Indraneel

Introduction: Patients with hyperinsulinism suffer recurrent and severe hypoglycaemia. Inpatient glucose monitoring is currently via intermittent, infrequent fingerprick self-monitoring blood glucose (SMBG), and risks missing hypoglycaemia between tests. Continuous glucose monitoring (CGM) offers a supplementary therapy which may identify unexpected hypoglycaemia and ultimately reduce total exposure. However, CGM has never been evaluated for its efficacy in th...