hrp0092p1-298 | Adrenals and HPA Axis (2) | ESPE2019

First Morning Pregnanetriol and 17-Hydroxyprogesterone Correlated Significantly Each Other with in 21-Hydroxylase Deficiency

Itonaga Tomoyo , Izawa Masako , Hamajima Takashi , Hasegawa Yukihiro

Background: Biochemically monitoring 21-hydroxylase deficiency (21OHD) treatment is challenging. Serum/blood 17-hydroxyprogesterone (17OHP) measurements, especially in the early morning before medication, are traditionally used for this purpose. Urinary pregnanetriol (PT), a urinary metabolite of 17OHP, may also be used. Based on auxological data, we previously reported that the first morning PT value in the range of 2.2–3.3 mg/gCr is optimal for monitori...

hrp0092p1-290 | Thyroid (1) | ESPE2019

Prediction of Permanent and Transient Congenital Hypothyroidism Based on Levothyroxine Dosages in Long-Term Follow-Up Patients: A Multicenter Retrospective Study in Japan

Higuchi Shinji , Itonaga Tomoyo , Shimura Kazuhiro , Nagasaki Keisuke , Satoh Mari , Takubo Noriyuki , Takahashi Ikuko , Sawada Hirotake , Hasegawa Yukihiro

Background: Congenital hypothyroidism (CH) can be categorized into two types: transient CH (group T) and permanent CH (group P). Several studies have recently demonstrated that the levothyroxine (LT4) dosage is useful for predicting LT4 requirement; however, none of the studies followed up their patients to puberty.Objective: To determine the cutoff value for the LT4 dosage as a predictor of LT4 requirement after puberty...