hrp0095s7.2 | Insight into Metabolic disorders and new therapeutic targets | ESPE2022

The circadian clock in insulin resistance and diabetes

Kalsbeek Andries , Jan Stenvers Dirk

In healthy humans, plasma glucose excursions depend on the time of day of glucose ingestion, with higher glucose tolerance in the morning compared to the evening. Recent studies using a circadian desynchrony protocol clearly demonstrated that the diurnal rhythm in glucose tolerance is robustly regulated by the circadian timing system, separate from behavioral and environmental changes. The mammalian circadian timing system consists of a central brain clock and peripheral clock...