hrp0092fc7.4 | Diabetes and Insulin Session 2 | ESPE2019

Metabolic Syndrome Features in Pre-Pubertal Children Born After Maternal Pre-Eclampsia

Goffin Sarah , Derraik José , Chiavaroli Valentina , Biggs Janene , Hofman Paul , Groom Katie , Cutfield Wayne

Background: Pre-eclampsia is associated with important complications for both mother and baby in the short term, but there are limited data about its long-term effects on offspring metabolism. Thus, we aimed to assess whether maternal pre-eclampsia was associated with adverse effects on metabolism and body composition in the offspring in childhood.Methods: We studied healthy pre-pubertal children (aged 4–10 years) b...

hrp0092lb-24 | Late Breaking Posters | ESPE2019

Abdominal Adiposity and Total Body Fat as Predictors of Cardiometabolic Health in Pre-Pubertal and Pubertal Youth

Jin Binghan , Derraik José G B , Fu JunFen , Lin Hu , Yuan Jinna , Dong Guanping

Objective: We aimed to investigate the usefulness of abdominal adiposity and total body fat as predictors of cardiometabolic health, especially insulin sensitivity, in children and adolescents.Methods: Participants were 479 children and adolescents with obesity (322 boys and 157 girls) aged 3 to 18 years attending the Children's Hospital at Zhejiang University School of Medicine (Hangzhou, China). Participants underw...

hrp0092p1-50 | Fat, Metabolism and Obesity | ESPE2019

Two-year Outcomes of Whanau Pakari: A Novel Home-based Intervention for Child and Adolescent Obesity

Anderson Yvonne , Wynter Lisa , O'Sullivan Niamh , Wild Cervantée , Grant Cameron , Cave Tami , Derraik José , Hofman Paul

Background: Whilst multi-disciplinary intervention models for children and adolescents with obesity remain recommended best practice, there is a lack of long-term outcome data, especially in home-based models and programs embedded within the clinical setting. Whānau Pakari is a community-based multi-disciplinary assessment/intervention programme for child obesity, focused on reducing health inequity. Based in Taranaki, Aotearoa/New Zealand, it focusses on...

hrp0092p1-229 | Growth and Syndromes (to include Turner Syndrome) (1) | ESPE2019

"Endocrine Evaluation of 29 Cornelia de Lange Syndrome Patients (CdLS) Patients"

Matamala Angela Marina Ascaso , de Ávila Montoya José Mario Romero , Cereza Maria Teresa Llorente , Lidón Laura Trujillano , Fuentes Feliciano Ramos , Juste Juan Pie , Lozano Gloria Bueno

Background: Cornelia de Lange (CdLS) syndrome (OMIM #122470) is a complex disease, characterized by distinctive facial features, failure to thrive, microcephaly, intrauterine growth retardation and anomalies in multiple organ systems. The complexity and severity of the endocrine commitment is variable. NIPBL, SMC1A, SMC3, RAD21 and HDAC8 genes, all involved in the cohesin pathway, have been identified to cause CdLS. There are few published studies on the endoc...

hrp0092p1-272 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology (1) | ESPE2019

Age at Menarche Over the Last Decades and Inter-Regional Variability in Northern Spain

Rubio Pablo Alonso , González Lucía Fernández , Saracho Cecilia Arbesú , Candás José Ignacio Pérez , Riaño-Galán Isolina

Introduction: Menarche is the time of first menstrual bleed and it occurs, on average, 2 to 2.5 years after the onset of puberty. Globally, the age of menarche had been reduced since the last century.Objective: To examine the evolution of the age of menarche over the last decades and inter-regional variability in an autonomous community located in northern Spain which is divided in eight health areas.<p class="abstex...

hrp0092p2-121 | Fat, Metabolism and Obesity | ESPE2019

A Non-invasive Model for Detection of the Metabolic Syndrome in Children and Adolescents

Lin Hu , Derraik José , Hong Ye , Liang Li , Gong ChunXiu , Luo FeiHong , Liu GeLi , Xiong Feng , Chen ShaoKe , Dong Guanping , Huang Ke , Wang Chunlin , Chen Xuefeng , Yuan Jinna Jinna , Fu Junfen

Objectives: We aimed to develop a non-invasive model for the detection of metabolic syndrome (MetS) in school children and adolescents.Methods: Participants were 7,330 children and adolescents aged 10–18 years attending schools in eight Chinese cities. Participants had anthropometry measured by research nurses and underwent fasting blood tests. MetS was defined as central obesity (waist-to-height ratio ≥0.46 f...

hrp0092p2-239 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Radiation Therapy for Children with Medulloblastoma: Growth and Thyroid Sequalae

Corredor-Andres Beatriz , Jerónimo Dos Santos Tiago , Alonso José Antonio , Cañas Mª Teresa , Muñoz-Calvo Mª Teresa , Argente Jesús

Background: Medulloblastoma is the most common malignant pediatric brain tumor. Although survival has improved with oncological therapy, late effects such as endocrine consequences are common, especially growth failure and thyroid dysfunction.Methods: Children diagnosed with medulloblastoma in a pediatric hospital between 2004 and 2014 were studied and followed until 2019. Statistical analysis was performed to estimate t...

hrp0092p3-119 | Fat, Metabolism and Obesity | ESPE2019

ESPE 2019. Physical Activity, Food and Metabolic Risk in Children and Adolescents

de Lamas Carmela , Vázquez Rocío , José Bedoya Juan , Aguilera Concepción , Gil-Campos Mercedes , Bueno Gloria , Moreno Luis , Gil Ángel , Leis Rosaura

Introduction:The incidence of obesity increases unstoppably in all populations and at all ages, and with it, the associated metabolic morbidity and mortality. The promotion of physical activity and a healthy diet are the fundamental elements to alleviate this situation. The objective of this study is to determine the relationship of physical activity and eating patterns with body composition, the degree of adiposity and certain metabolic risk factors.<p cl...

hrp0092p1-135 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Combining Clinical and Genetic Approaches in Diagnosing a Large Brazilian Cohort of Patients with 46,XY Differences of Sex Development (DSD)

Gomes Nathalia Lisboa , Batista Rafael Loch , Nishi Mirian Y , Marcondes Antonio , Silva Tatiane E. , Funari Mariana , Faria Júnior José Antônio Diniz , Silva Daniela Moraes , Montenegro Luciana , Frade Costa Elaine Maria , Jorge Alexander Augusto , Domenice Sorahia , Mendonca Berenice Bilharinho

Background: Most published studies on 46,XY DSD focused on genetic findings without association with biochemical work-up.Objectives: To retrospectively analyze the clinical and genetic findings of a large cohort of 46,XY DSD patients.Methods: 285 non-syndromic 46,XY DSD individuals (192 sporadic and 89 familial cases) were studied. LH, FSH, testosterone (T), androstenedione (A) wer...