ESPE Abstracts

Objectives: Vascular endothelial growth factor-A (VEGF-A) is essential for normal growth plate morphogenesis and angiogenesis in adipose tissue. Childhood obesity may lead to early puberty in girls, however, it remains unclear whether early thelarche in overweight girls is related to central activation of the gonadotropin releasing hormone-gonadotropin axis. We assessed serum VEGF-A level regarding to pubertal stage and obesity in girls....