hrp0089p3-p303 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Morning Basal Luteinizing Hormone, A Good Screening Tool for Diagnosing Central Precocious Puberty

Hyuk Jung In , Min Lee Dong

Background: The current standard method to diagnose central precocious puberty(CPP) is gonadotropin releasing hormone stimulation test (GnRHST). But, it is inconvenient for children because of time-consuming and multiple samples. This study aimed to present utility of morning basal luteinizing hormone (LH) for the screening of central precocious puberty with emphasis on the influence of diurnal variation.Methods: This study is a retrospective review of 1...

hrp0094p1-192 | Thyroid B | ESPE2021

Analysis of hypothyroidism NGS test in Korean patients with congenital hypothyroidism in a single center

Jung So Yoon , Lee Jeongho ,

Introduction: Thyroid hormone is known as greatly influence on growth and development in fetuses and newborns. If the detection of the disease is delayed, hypothyroidism can cause irreversible damage, so early detection and treatment is very important. Hypothyroidism can be divided into permanent and temporary cases depending on the duration of treatment, but there is no predictor that can completely differentiate those two. However, as genes related to hypoth...

hrp0092p3-34 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Study of Response to Vitamin D Replacemet in North Korean Refugee Children and Korean Children

Hee Chung Myung , Hup Song Jung

Study of response to vitamin D replacemet in North Korean refugee children and Korean childrenMyung Hee Chung, MD., Ph.DDaegu Medical Center, Daegu Metropolitan city, KoreaJung Hup Song, MD., Ph.DKyungpook National university hosptal,Occupational Medicine, Public Health Dept.,Daegu, KoreaPurpose: It is well known that obesity and ...

hrp0089p2-p276 | Growth & Syndromes P2 | ESPE2018

Earlier Mother’s Age at Menarche is a Risk Factor of Daughter’s Early Menarche and Short Stature in Young Korean Female: Epidemiologic Study

Lim Jung Sub , Hwang Jin Soon

Objective: To investigate whether earlier mother’s age at menarche is a risk factor of daughter’s early menarche, obesity, and short stature in young Korean female.Research design and methods: We tested associations between mother’s age at menarche, mother’s adult body size and her daughter’s age at menarche, body size from the data of 6th Korea National Health and Nutrition Examination Survey (KNHANES VI) (2013–2015). We an...

hrp0095p1-126 | Growth and Syndromes | ESPE2022

Earlier menarche of mothers as a risk factor for daughters’ early age at menarche and short stature in young Korean females: an epidemiologic study

Sub Lim Jung , Hyun Kim Ji

Background: Early age at menarche was associated with obesity, insulin resistance, metabolic syndrome, cardiovascular disease (CVD), and mortality in adulthood. Besides, a mother's age at menarche has been suggested to be a likely contributor to a daughter's early menarche. Therefore, this study aimed to determine whether a mother's earlier age at menarche is a risk factor for a daughter's early menarche, obesity, and short stature in young...

hrp0092fc1.2 | Diabetes and Insulin Session 1 | ESPE2019

Three New Genes (PTPRD, SYT9, and WSF1) Related to Korean Maturity-Onset Diabetes in the Young (MODY) Children Decrease Insulin Synthesis and Secretion in Human Pancreatic Beta Cells

Jang Kyung-Mi , Moon Jung-Eun , Lee Su-Jung , Lee Ji-Min , Ko Cheol-Woo

Background: MODY includes a very heterogenous group of monogenic diabetes mellitus characterized by beta-islet cell dysfuction. We previously reported 3 new gene mutations of PTPRD, SYT9 and WFS1 in Korean MODY children (Horm Res Paediatr,2015). We investigated whether the PTPRD, SYT9 and WFS1 mutation overexpression vectors affect insulin synthesis and secretion in human pancreatic beta cells.Materials & Methods: We...

hrp0092t14 | Top 20 Poster | ESPE2019

The Effect of Endocine Disrupting Chemicals to Precocious Puberty in Children with Exposure History of 'Slim'

Lee Su-Jung , Lee Ji-Min , Moon Jung-Eun , Ko Cheol-Woo

Background: Recently, the puberty is becoming to start earlier. This early beginning of the puberty is multifactorially related to genes, hormones and environmental factors. It has been already known in many animal experiments that endocrine disrupting chemicals (ECDs) are deeply envolved in regulation of endocrine systems. However, clinical studies in humans are limited. Recently, the toy of 'Slim' which thought to contain ECDs such as phthalates is v...

hrp0082p3-d2-859 | Growth (3) | ESPE2014

Response of GH Therapy in Six Children with Achondroplasia

Kim Yoon Jung , Cho Byung Wook , Kim Ji Yoon , Kim Heung Sik , Lee Hee Jung

Background: Achondroplasia is the most common condition characterized by disproportionate short stature. Patients with achondroplasia progressively fall below normal standards for length and height. GH has been widely used to treat short stature with or without GH deficiency (GHD).Objective and hypotheses: The purpose of the present study was to clarify the effectiveness of GH therapy on short stature in achondroplasia.Method: The ...

hrp0082p1-d1-234 | Thyroid | ESPE2014

Association of Toll-Like Receptor-10 Polymorphisms with Autoimmune Thyroid Disease in Korean Children*

Cho Won Kyoung , Jeon Yeon Jin , Jung In Ah , Kim Shin Hee , Jang Jung-Pil , Choi Eun-Jeong , Jung Min Ho , Kim Tai-Gyu , Suh Byung-Kyu

Background: The Toll-like receptors are germline-encoded receptors that play an essential role in initiating the immune response against pathogens.Objective and hypotheses: We aimed to assess the association of TLRs polymorphism with autoimmune thyroid disease (AITD) in Korean children.Method: We define the polymorphism of TLR10, rs4129009, rs11096956, rs10004195 in 85 Korean AITD (GD=50, HD=35; M=16, F=69, mean age=12.9 3.1 years)...

hrp0092p1-203 | Fat, Metabolism and Obesity (1) | ESPE2019

Serum Nonylphenol and Obesity in Children and Adolescents

Seo Moon Young , Kim Shin-Hye , Park Mi Jung

Background: Experimental models suggest that exposure to low dose nonylphenol could induce adiposity and promote adipocyte differentiation in mice. However, studies on the effect of nonylphenol exposure to human obesity have not been adequately studied.Objective: We investigated the associations of serum nonylphenol concentration with adiposity measures in Korean children and adolescents.Me...