hrp0086fc11.4 | Thyroid | ESPE2016

Decreased Proportions of CD4+IL17+/CD4+CD25+CD127− and CD4+IL17+/CD4+CD25+CD127-FoxP3+T Cells in Children with Autoimmune Thyroid Diseases

Bossowski Artur , Moniuszko Marcin , Grubczak Kamil , Snight Paulina , Bossowska Anna , Diana Tanja , Kahaly George

Background: Until now, altered balance of Th1 and Th2 immune cells has been postulated to play an important role in the pathogenesis of autoimmune thyroid diseases (AITD). However, recent studies on thyroid diseases have suggested a new role for Th17 cells that have been classified as a new lineage, distinct from Th1, Th2 and Treg cells. Despite wide interest, the role of Th17 cells in the pathogenesis of inflammatory and autoimmune diseases is still debated.<p class="abst...

hrp0086p2-p953 | Thyroid P2 | ESPE2016

Clinical Value of Thyroid-Stimulating Immunoglobulin in Paediatric Autoimmune Thyroid Diseases

Stozek Karolina , Bossowski Artur , Ziora Katarzyna , Bossowska Anna , Diana Tanja , Kahaly George J

Background: In Autoimmune Thyroid Disease (AITD) two types of TSH receptor antibodies (TSHR-Ab) may be distinguished: thyroid- stimulating immunoglobulin (TSI) that promotes the production of thyroid hormones and thyroid- blocking immunoglobulin (TBI) inhibiting the activity of TSH what leads contrarily to hypothyroidism.Objective and hypotheses: The aim of this study was to compare mean TSI and TBI levels in large paediatric cohort with AITD and control...

hrp0097p1-589 | Thyroid | ESPE2023

Thyrotropin receptor stimulating antibodies in pediatric patients with Graves’ diseases using ultra-rapid turbo bioassay

Bossowski Artur , Hatun Burak , Sawicka Beata , Stożek Karolina , Bossowski Filip , J Kahaly George

Background: Thyrotropin receptor (TSH-R) stimulating autoantibodies (TSAb) are present in 90-100% of patients with Graves’ disease (GD). TSAb are functional, impact thyroid function, and are clinically relevant. This study we performed in a pediatric patients with dynamic of Graves’ disease before and during methimazole therapy and in patient with Hashimoto’s thyroiditis using a novel and ultra-rapid TSAb andTBAb bioassay.<p class="abstex...

hrp0092p1-148 | Thyroid | ESPE2019

Activating mutation M453V in receptor TSHR as a cause familial hyperthyroidism

Sawicka Beata , Stephenson Alexandra , Borysewicz- Sanczyk Hanna , Michalak Justyna , Stozek Karolina , Tanja Diana , Kahaly George , Paschke Ralf , Bossowski Artur

The most common hyperthyroidism in children is Graves' disease. The other rare cause of hyperthyroidism is activating mutation in receptor TSHR in thyroid gland.We would like to introduce a case of familial hyperthyroidism with a novel mutation M453V in the TSHR in three membersActually 11-year-old boy is a patient in outpatient clinic for first days after birth. During gestation his mother was treated with thyreostatic drugs b...