hrp0086p1-p105 | Bone & Mineral Metabolism P1 | ESPE2016

Effects of Selective GPER-1 Agonist G1 on Bone Growth

Iravani Maryam , Karimian Elham , Chagin Andrei , Savendahl Lars

Background: Abnormal growth is a common problem in children. Some children do not respond to growth hormone therapy and alternative treatments selectively targeting the growth plate are needed. High doses of estrogens induce growth plate closure and stop further growth. However, high-dose estrogen treatment may also have severe side effects, including increased risk of cancer and reduced fertility. The expression of estrogen receptors (ER), including GPER-1, has been demonstra...