hrp0082p1-d2-3 | Adrenals & HP Axis | ESPE2014

Transient Generalized Glucocorticoid Hypersensitivity: Clinical Manifestations, Endocrinologic Evaluation, and Transcriptomic Profile: the Potential Role of nf-κb

Nicolaides Nicolas C , Lamprokostopoulou Agaristi , Polyzos Alexandros , Kino Tomoshige , Katsantoni Eleni , Triantafyllou Panagiota , Christophoridis Athanasios , Katzos George , Drakopoulou Maria , Sertedaki Amalia , Chrousos George P , Charmandari Evangelia

Background: Transient generalized glucocorticoid hypersensitivity is a rare disorder characterized by increased tissue sensitivity to glucocorticoids and compensatory hypoactivation of the hypothalamic┬ľpituitary┬ľadrenal (HPA) axis. The condition itself and the molecular mechanisms that underlie its pathophysiology have not been elucidated as yet. Adenovirus 36 has been reported to cause obesity in various animal species.Objective and Hypotheses...