ESPE Abstracts

Menarche is a late pubertal event that occurs at an average age of 12.4 years and follows on an average of 2.5 years after the onset of breast development. When it occurs before the age of 10 years, it is considered early menarche. Isolated premature menarche is defined as onset of vaginal bleeding in a prepubertal female, in the absence of appropriate secondary sexual characters or a known pathological cause. It can present with isolated or recurrent periodic episodes of blee...

Introduction: Insulin stress test (IST) to diagnose growth hormone (GH) deficiency is rarely used by paediatric endocrine teams in the United Kingdom, due to concerns over safety. We share our experience of undertaking modified IST in children, with regards to safety and outcomes.Methods: We adapted the protocol for insulin stress test, proposed by Galloway et al to undertake pituitary stimulation test for our c...