hrp0089p3-p168 | Fat, Metabolism and Obesity P3 | ESPE2018

Beneficial Effect of Metformin Treatment in Obese Children and Adolescents

Todorova Zdravka , Stefanova Elissaveta , Kazakova Krassimira , Jordanova Desislava , Dimitrova Mihaela

Introduction: Obesity in children and adolescents is a growing global health problem. Obese children and adolescents provide the pediatric healthcare professionals management challenge. Obesity with insulin resistance, dyslipidemia and elevated blood pressure constitute the metabolic syndrome and each of these is an independent risk factor for cardiovascular disease, diabetes mellitus, non-alcoholic fatty liver disease. Lifestyle modification is a primary and main milestone in...

hrp0082p3-d1-631 | Adrenals & HP Axis | ESPE2014

Homozygous c.923dupT Combined with Heterozygous c.334G>A CYP21A2 Mutation: a Case Report from the Bulgarian CAH Screening Programme

Kostova Antoaneta , Stoeva Iva , Kirov Andrey , Dineva Ganka , Todorov Tihomir , Todorova Albena , Stefanova Elissaveta , Kazakova Krassimira , Aroyo Ani , Mitev Vanio

Background: This case underlines the importance of a newborn screening programme combined with genotyping for confirmation and prognosis of disease severity.Objective and hypotheses: Case presentation of a girl with three CYP21A2 mutations.Method: Girl, born from first uneventful pregnancy per vias naturalis. Birthweight 3200 g, birthlenght 50 cm. Intensive jaundice, start at d3, necessitating phototherapy. Discharged from...