hrp0098p1-299 | Late Breaking 1 | ESPE2024

A Real-World Pharmacovigilance Assessment and Literature Review of Lymphoma Development in Lipodystrophy and Congenital Leptin Deficiency

J. Brown Rebecca , Araujo-Vilar David , Walkovich Kelly , Barbarosie Alexandru , A. Magee David , Akinci Baris , A. Oral Elif

Introduction: Metreleptin is a leptin replacement therapy used as an adjunct to diet to treat the metabolic complications of leptin deficiency in lipodystrophy, a rare disease characterised by loss of adipose tissue. Previously, identification of T-cell lymphomas in three metreleptin-treated patients with acquired generalised lipodystrophy (AGL) led to concerns of a potential link between metreleptin and lymphoma development.Meth...