hrp0092p1-256 | Pituitary, Neuroendocrinology and Puberty (1) | ESPE2019

Kisspeptin Levels is a New Diagnostic Approach of Hypogonadotropic Hypogonadism in Boys

Nikitina Irina , Yukhlina Yulya , Nagornaya Irena , Kelmanson Igor , Grineva Elena

Background: In hypogonadotropic hypogonadism (HH), hypophyseal follicle-stimulating and luteinizing hormones, normally released with GnRH stimulation, are detected low. Since kisspeptin (KP) is a strong stimulant of GnRH neurons, it is considered to have a role in HH aetiology. It may be hypothesized that abnormal plasma levels of KP are indicative of HH.Aim: Evaluation and comparison of plasma KP levels in boys of pre-p...

hrp0095p1-237 | Diabetes and Insulin | ESPE2022

Neurodevelopmental outcomes in children with congenital hyperinsulinism.

Nikitina Irina , Sarakaeva Leyla , Eftich Egine , Bairov Vladimir , Sukhotskaya Anna , Smorodin Andrey , Ryzhkova Darya , Mitrofanova Lubov , Kelmanson Igor

Background: Congenital hyperinsulinism (CHI) is a rare group of genetic disorders resulting in persistent hypoglycemia which can lead to a considerable risk of neurological damage and developmental delay.Aim: To assess the neurodevelopmental outcome in children with CHI.Methods: Thirty-three patients with СHI aged from 7 to 58 months were included. All subjects underwent clinic...