hrp0095p1-48 | Diabetes and Insulin | ESPE2022

Maternal Hepatic HKDC1 Expression Impacts Offspring Glucose Metabolism

Jo Inha , Khan Md. , Layden Brian

Gestational Diabetes (GDM) increases risk of developing type 2 diabetes in the mother and child later in life however, despite the increasing prevalence of GDM, its molecular mechanism remains unknown. A recent Genome-Wide Association Study (GWAS) identified a unique genetic association of the novel 5th hexokinase, hexokinase domain component-1 (HKDC1) to gestational glucose tolerance at 28 weeks of gestation linking it to GDM. We have previously shown that liver-specific over...