hrp0089fc13.5 | Pituitary, Neuroendocrinology and Puberty 2 | ESPE2018

Study of the Serum Kisspeptin Level in Healthy and Hypogonadotropic Boys

Nikitina Irina , Khoduleva Yulia , Nagornaya Irena , Vasileva Elena

Background: Kisspeptins, ligands of G protein-coupled receptor 54 (GPR54) encoded by the KiSS-1 gene, have recently emerged as key players of the gonadotropic axis. It was found that KiSS-1/GPR54 system plays an important role in the neuroendocrine control of gonadotropin secretion, brain sex differentiation, puberty onset and fertility. It is important to know if the kisspeptin serum level could be used as a diagnostic criterion to the stage of puberty or impairment of it in ...

hrp0086p2-p412 | Gonads & DSD P2 | ESPE2016

Towards the Roles of Kisspeptins in the Control of Gonadotropic Axis: Focus on Peripheral Signaling in Androgen-Dependent Tissues in the Experimentally Induced Model Hypogonadotropic Hypogonadism in Male Rats

Nikitina Irina , Khoduleva Yulia , Nagornaya Irina , Bairamov Alekber , Shabanov Petr , Masel Alisa

Background: Recently kisspeptins are considered as a key gatekeepers of the regulation of the gonadotropic axis.Objective and hypotheses: To investigate the impact of experimentally induced hypogonadism on kisspeptins signaling in androgen-dependent tissues and blood.Method: Wistar male rats (29 in total) were used. Rats were divided into four groups. Group 1 (control, prepubertal rats aged 2 months, n=7). Group 2 (control...