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hrp0098p1-304 | Late Breaking 2 | ESPE2024

ER stress relief drives ß-cell proliferation

Bourgeois Stephanie , Staels Willem , Van Mulders Annelore , Willems Lien , Coenen Sophie , Degroote Laure , Pierreux Julie , Leuckx Gunter , Heremans Yves , De Leu Nico , Heimberg Harry , Cnop Miriam , Yi Xiaoyan , Movahedi Kiavash , Kancheva Daliya , Scheyltjens Isabelle , de Koning Eelco , Carlotti Françoise

Introduction: Regenerating endogenous pancreatic β-cells is a potentially curative yet currently elusive strategy for diabetes therapy. Mimicking the microenvironment of the developing pancreas and leveraging vascular signals, critical to pancreatic endocrinogenesis, may promote β-cell regeneration. We aimed to investigate whether recovery from experimental hypovascularization of the endocrine pancreas could trigger mouse ß-cell proliferation.<...

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ER stress relief drives ß-cell proliferation

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