ESPE Abstracts

Background: We have identified a novel tandem duplication leading to ubiquitous expression of the agouti-signaling protein (ASIP) in a female patient with severe early onset obesity, red hair, tall stature, and insulin resistance (Kempf, E. et al, 2022). Due to the ectopic expression, ASIP - which normally is only expressed in the skin - can interact with the Melanocortin-4-Receptor receptor in the hypothalamus thereby causing the obesity phenotype.<p clas...

Background: The prevalence of childhood and adulthood obesity as a chronic condition is rising worldwide with comorbidities and impairment of psychosocial development starting already early in life. The transition from adolescence to adulthood is a vulnerable period for young individuals with chronic conditions, yet the transition of children with obesity remains poorly studied. We aimed to characterize the transition of children with overweight/obesity from a...