hrp0094p1-147 | Sex Endocrinology and Gonads B | ESPE2021
, Kleber Michaela
, Rothermel Juliane
, Holterhus Paul-Martin
, Kulle Alexandra
Introduction: In children, estradiol (E2) concentrations are 1000-times lower in comparison to their precursors, the androgens. Depending on sex, age, and pathology, plasma concentrations vary in a broad range. The sensitive and specific determination of E2 is a particular challenge in pediatric endocrinology. Here we report a female patient aged 12 6/12 years and Tanner stage B1 with a presumed diagnosis of ovarian insufficiency. She showed a very high E2 con...