hrp0086p2-p785 | Pituitary and Neuroendocrinology P2 | ESPE2016

Hyperleptinemia in Obese and Non-Obese Children with Early Puberty

Jang Kyung-Mi , Moon Jung-Eun , Ko Cheol-Woo

Background: Leptin is mainly produced by adipocytes. In animal and human, it is a potnet anorectic and increases in obesity. Some reported that precocious puberty is prevelent in children with obesity.Objective and hypotheses: This study was done to see the changes of blood leptin levels in both obese and non-obese children with early puberty or precocious puberty.Method: Study patients consist of 325 children with early puberty or...

hrp0084p3-1165 | Puberty | ESPE2015

One Year Follow-Up of Asymptomatic Precocious Puberty; Clinical and Laboratory Characteristics

Jang Kyung-Mi , Cho Eun-Mi , Ko Cheol-Woo

Background: Children with bone-age advancement without any pubertal sign (asymptomatic precocious puberty, asmyptomatic PP) were reported (CW Ko,et al, at the Annual Meeting of ESPE, 2012 and 2013).Objective and hypotheses: In our follow-up study, some more children with asmyptomatic PP were enrolled additionally. We analysed their clinical and laboratory characteristics at the time of diagnosis, and they were followed-up prospectively t...

hrp0095p1-119 | Growth and Syndromes | ESPE2022

Post-hoc subgroup analysis of Asian subjects from the pivotal phase 3 study of once-weekly somatrogon vs once-daily Genotropin

Gomez Roy , Khadilkar Vaman , Shembalkar Jayashri , Chu Der-Ming , Woo Ko Cheol , Wajnrajch Michael , Wang Ronnie

Objectives: Somatrogon is a long-acting recombinant human growth hormone (GH) approved by the EMA as a once weekly treatment for children with pediatric GH deficiency (GHD). A global phase 3 study compared the efficacy and safety of once-weekly somatrogon with once-daily Genotropin in pediatric subjects with GHD. The objective of this subgroup analysis was to evaluate the efficacy and safety of once-weekly somatrogon vs once-daily Genotropin in the subset of A...

hrp0092fc1.2 | Diabetes and Insulin Session 1 | ESPE2019

Three New Genes (PTPRD, SYT9, and WSF1) Related to Korean Maturity-Onset Diabetes in the Young (MODY) Children Decrease Insulin Synthesis and Secretion in Human Pancreatic Beta Cells

Jang Kyung-Mi , Moon Jung-Eun , Lee Su-Jung , Lee Ji-Min , Ko Cheol-Woo

Background: MODY includes a very heterogenous group of monogenic diabetes mellitus characterized by beta-islet cell dysfuction. We previously reported 3 new gene mutations of PTPRD, SYT9 and WFS1 in Korean MODY children (Horm Res Paediatr,2015). We investigated whether the PTPRD, SYT9 and WFS1 mutation overexpression vectors affect insulin synthesis and secretion in human pancreatic beta cells.Materials & Methods: We...

hrp0092t14 | Top 20 Poster | ESPE2019

The Effect of Endocine Disrupting Chemicals to Precocious Puberty in Children with Exposure History of 'Slim'

Lee Su-Jung , Lee Ji-Min , Moon Jung-Eun , Ko Cheol-Woo

Background: Recently, the puberty is becoming to start earlier. This early beginning of the puberty is multifactorially related to genes, hormones and environmental factors. It has been already known in many animal experiments that endocrine disrupting chemicals (ECDs) are deeply envolved in regulation of endocrine systems. However, clinical studies in humans are limited. Recently, the toy of 'Slim' which thought to contain ECDs such as phthalates is v...

hrp0092p3-305 | Late Breaking Abstracts | ESPE2019

Combined Surgical and Medical Treatment in an Adolescent with Severe Gynecomastia Due to Excessive Estradiol Secretion: A Case Report

Lee Miseon , Moon JungEun , Woo Ko Cheol , Seok Lee Joon , Dug Yang Jung

Background: Gynecomastia develops due to the reversed estradiol-to-Testosterone ratio in adolescence, and symptoms typically improve within two years. The causes vary widely, including estrogen excess and tumors, and surgical treatment is usually given in late adolescence because postoperative symptoms may recur in adolescents. There are no guiding recommendations for gynecomastia to date besides the suggestion to consider rapidly growing gynecomastia and brea...

hrp0089p2-p047 | Bone, Growth Plate & Mineral Metabolism P2 | ESPE2018

A Novel Variant of SLC34A1 Gene in an Infant with Idiopathic Infantile Hypercalcemia

Lee Gi-Min , Moon Jung-Eun , Kim Hyeon-A , Lee Su-Jeong , Ko Cheol-Woo

Bacground and objective: Idiopathic infantile hypercalcemia is one of rare diseases characterizing hypercalcemia in infancy. Renal phosphate absorption in proximal tubules plays a very important role in the phosphate and calcium homeostasis. SLC34A1 is known a key regulator of renal phosphate reabsorption. SLC34A1 gene mutation is one of very uncommon causes of idiopathic infantile hypercalcemia. We have experienced a case of idiopathic infantile hypercalcemia caused by a homo...

hrp0089p1-p057 | Diabetes & Insulin P1 | ESPE2018

Three New Gene Variants (PTPRD, SYT9, and WFS1) Related to Korean MODY Children Decrease Insulin Secretion in Human Pancreatic Beta Cells

Jang Kyung-Mi , Moon Jung-Eun , Lee Su-Jeong , Lee Gi-Min , Ko Cheol-Woo

Background & objective: Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes that is characterized by an early onset, autosomal dominant mode of inheritance and a primary defect in pancreatic β-cell function. MODY has been identified in Asian populations, however, there is a big discrepancy in the genetic locus between Asian and Caucasian patients with MODY. We previously reported that mutations in PTPRD, SYT9 and WFS1 have been identified in Ko...

hrp0089p3-p101 | Diabetes & Insulin P3 | ESPE2018

Changes in Glycemic Control after Switching from NPH & RI to Insulin Glargine and Lispro in Children with Type 1 Diabetes Mellitus (T1DM)

Kim Hyeon-A , Moon Jung-Eun , Lee Soo-Jeong , Lee Gi-Min , Ko Cheol-Woo

Background and objective: It has been reported that glycemic control gets better in children with T1DM on insulin glargine and lispro when compard to patients on NPH and RI. This study was conducted to see the changes of glycemic control after switching from insulin glargine and lispro (GLAR/LIS) to NPH and RI (NPH/RI) in Korean children with T1DM.Materials and methods: We studied 14 patients who were diagnosed with T1DM in Kyungpook National Children&#1...

hrp0089p1-p150 | GH & IGFs P1 | ESPE2018

Total Sum of Growth Hormone Values Obtained from Growth Hormone Stimulation Test May be Useful in the Diagnosis of Prepubertal Children with Idiopathic Growth Hormone Deficiency

Lee Su-Jeong , Moon Jung-Eun , Lee Gi-Min , Kim Hyeon-A , Ko Cheol-Woo

Background and objective: The peak GH value plays a crucial role in the diagnosis of idiopathic growth hormone deficiency (iGHD). However, the prediction of peak GH in iGHD diagnosis is known to be limited. The purpose of this study was to evaluate the clinical and diagnostic usefulness of the total sum of GH values obtained from the GH stimulation test.Materials and methods: We retrospectively reviewed 178 prepubertal children who were diagnosed with iG...