hrp0097p2-273 | Late Breaking | ESPE2023

Key parameters at puberty onset can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism

d'Aniello Francesco , Aung Yuri , Kokotsis Vasilis , R Howard Sasha

Introduction: Delayed puberty (DP), affecting over 2% of adolescents, is defined as pubertal onset 2-2.5 SDs later than the general population. The most common underlying aetiology is self-limited DP (SLDP). However, this can be difficult to differentiate from the more severe condition congenital hypogonadotrophic hypogonadism (HH), especially on first presentation of an adolescent patient with DP. This study sought to elucidate phenotypic and genotypic discre...