hrp0089p2-p335 | Pituitary, Neuroendocrinology and Puberty P2 | ESPE2018

The Effect of Polychlorinobiphenyls on Premature Puberty in Girls

Guven Raziye Burcu , Ozen Samim , Gokşen Damla , Korkmaz Ozlem , Darcan Şukran

Introduction: Studies show that onset of puberty in girls is occurring at increasingly younger ages. Environmental endocrine disruptors are implicated in the etiology of early puberty. Polychlorobiphenyls (PCBs) are one of the endocrine disruptor with proven estrogenic effects.Aim: To investigate the effect of PCBs on premature puberty in girls.Materials-Methods: The study group was selected from girls aged 2–8 years with a di...

hrp0086p2-p389 | Gonads & DSD P2 | ESPE2016

Persistent Mullerian Duct Syndrome with Transverse Testicular Ectopia: A Novel AMH Receptor Mutation

Korkmaz Ozlem , Ozen Samim , Ozcan Nurhan , Bayindir Petek , Sen Sait , Onay Huseyin , Goksen Damla , Avanoglu Ali , Ozkinay Ferda , Darcan Sukran

Background: Persistent Mullerian duct syndrome is the result of either anti-Mullerian hormone (AMH) deficiency or AMH receptor resistance. While the external genital structure is that of a normal virilized male, fallopian tubes and a uterus are observed in the internal genital structure. We present a case referred to our clinic because of female internal genital structure at laparoscopy during a surgical procedure performed due to undescended testes.Obje...

hrp0098rfc14.2 | Fetal and Neonatal Endocrinology | ESPE2024

Does gestational diabetes mellitus influence mitochondrial dynamics in offspring?

Abali Saygin , Oz-Arslan Devrim , Guner-Yilmaz Bengisu , Celik Musa , Koç Berkcan , Muftuoglu Meltem , Pata Ozlem , Korkmaz-Toygar Ayse , Semiz Serap , Kan Beki , Beken Serdar

Introduction: Gestational diabetes mellitus (GDM) is a common problem in pregnancy with metabolic consequences for the fetus and the postnatal period. The aim of this study was to investigate the effects of GDM on mitochondrial structure and function in cord blood mononuclear cells and placental tissue, and the relationship between clinical data and mitochondrial dynamics.Method: In this prospective cohort study, singlet...