ESPE Abstracts

Background: The duodenal–jejunal bypass liner (DJBL) is an endoscopically placed and removable intestinal liner that creates a duodenal–jejunal bypass. Weight loss and diabetes improvement was reported in the adults.Objective and hypotheses: To evaluate clinical effects and safety of this device in severely obese adolescents with obesity complications.Method: Six morbidly obese adolescents (four female, mean age 18.2 year...

Background: Treatment of adolescents with obesity with duodenal-jejunal bypass liner (DJBL) is effective in terms of lowering body mass index (BMI) and improving the metabolic complications of obesity.Objective and hypotheses: To quantify the temporal and quantitative changes in the expression of cytokines associated with appetite and insulin resistance and C-reactive protein (CRP) after insertion of DJBL in correlation ...

Background: Novo Nordisk’s long-acting growth hormone (LAGH) is approved by EMA for treating growth hormone deficiency (GHD) in children 3 years and older. The LAGH connected system includes the innovative add-on Mallya connectivity cap (manufactured by BIOCORP, a Novo Nordisk Company), which connects to the pen injector, detects the dose and dose time, and sends data to mobile application via Bluetooth. This marks the first LAGH connected device in Slov...

Background: Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene and results in a progressive muscular damage and degeneration. Endocrine complications result from decreased energy expenditure, immobility and glucocorticoid (GC) treatment. Due to the multidisciplinary management and emerging genetic and molecular therapies longer survival is expected and there is an increasing emphasis on the quality of life in DMD. Aim of the study ...

Introduction: Recently novel approaches, through implementation of next-generation sequencing (NGS) in clinical practice for genetic evaluation of idiopathic short stature, has permitted to identify new variants of genes which modulate function of growth plate, including heterozygous mutations of the aggrecan gene. Aggrecan, a large chondroitin sulfated proteoglycan, is a major structural component of the extracellular matrix of cartilage, including growth pla...

Objective: Childhood brain tumor survivors have an increased risk for developing cardiovascular disease, as a consequence of the primary disease itself and/or its treatment. Early detection of children at risk is important to take preventive measures. Carotid intima-media thickness (cIMT), determined with ultrasound, is a non-invasive biomarker of atherosclerosis in its subclinical stage. The study aimed to evaluate metabolic complications and determine cardio...

Objective: Determining the cause of early obesity in children is of paramount importance for early and efficient treatment, including novel targeted pharmaceutical treatment options (e.g. MCR4 agonist). Here, we report findings from diagnostic whole exome sequencing of children with obesity, identifying genetic variants both within and outside the leptin-melanocortin pathway associated with obesity. These findings provide valuable insights for informe...