hrp0094p1-74 | Fetal Endocrinology and Multisystem Disorders A | ESPE2021

Pancreatic glucagon-like-peptide-1 receptor expression in congenital hyperinsulinism

Gubaeva Diliara , Proshchina Alexandra , Krivova Yuliya , Melikyan Maria ,

Background: Congenital hyperinsulinism (CHI) is the most common cause of neonatal persistent hypoglycaemia. Current treatment lacks efficiency, and so are methods for differential diagnosis of diffuse and focal histological forms. Novel diagnostic and treatment approaches with the use of another hormone – glucagon-like-peptide-1 (GLP-1) – have been developed. GLP-1 is one of the key factors for maintaining euglycaemia. It stimulates insulin secretion...