hrp0089p3-p085 | Diabetes & Insulin P3 | ESPE2018

A Sibling Case of Wolfram Syndrome with Diabetes Mellitus Diagnosed within 10 Months in Early Childhood

Suzuki Dai , Shima Hirohito , Umeki Ikumi , Kamimura Miki , Kanno Junko , Kure Shigeo , Fujiwara Ikuma

Introduction: Wolfram syndrome (WS) is a rare progressive neurodegenerative disease that shows autosomal recessive inheritance characterized by diabetes insipidus, diabetes mellitus (DM), optic nerve atrophy and deafness. WFS1 gene encoding a protein, wolframin, which is essential to the function of the endoplasmic reticulum, is identified as main causative gene of the disease. We report here a sibling case suspected WS with insulin-dependent DM and optic atrophy in early chil...

hrp0084p2-235 | Bone | ESPE2015

Assessment of Foramen Magnum in Early Infancy is Efficient for Patients with Achondroplasia

Sogi Chisumi , Kamimura Miki , Hakoda Akiko , Kanno Junko , Fujiwara Ikuma , Kure Shigeo

Background: Achondroplasia is the most common form of human short-limbed dwarfism. The most serious complication in individuals with achondroplasia is narrowing of foramen magnum (FM) that results in cervicomedullary compression and sudden infant death. To avoid sudden infant death, early monitoring and implementation of the necessary medical intervention are important. However, the optimal method of screening for cervicomedullary compression continues to be debated.<p cla...

hrp0092p2-285 | Thyroid | ESPE2019

Serum PTH Does not Correlate with Their Serum Calcium Levels in Children and Adolescents with Hashimoto Thyroiditis

Shima Hirohito , Sogi Chisumi , Umeki Ikumi , Suzuki Dai , Kamimura Miki , Saito-Hakoda Akiko , Kanno Junko , Kure Shigeo , Fujiwara Ikuma

Background: Hashimoto thyroiditis (HT) is characterized by autoimmune-mediated destruction of the thyroid gland. Ca metabolism disturbance due to hypoparathyroidism among HT patients remains to be clarified.Objective: To clarify the relationship between HT and primary hypoparathyroidism.Patients and Methods: Serum levels of Ca, albumin, and whole PTH (wPTH, ECLIA) were measured in ...

hrp0092p3-27 | Adrenals and HPA Axis | ESPE2019

A Boy with Adrenal Hypoplasia Congenita without External Genital Abnormalities

Umeki Ikumi , Kanno Junko , Shima Hirohito , Suzuki Dai , Kamimura Miki , Homma Keiko , Hasegawa Tomonobu , Fujiwara Ikuma , Kure Shigeo

Background: Adrenal hypoplasia congenita (AHC) is a rare disorder with an estimated frequency of 1 case per 12,500 live births. AHC causes 46,XY disorders in sex development (DSD) due to adrenal androgen deficiency.Objective: Case report ona male AHC patient with no external genitalia abnormalities.Case report: The baby was born at 37 weeks'gestation with a height of 46.5 cm (-...

hrp0089p1-p186 | Growth &amp; Syndromes P1 | ESPE2018

Maternal Uniparental Disomy for Chromosome 20: Physical and Endocrinological Characteristics of Six Patients

Kawashima Sayaka , Nakamura Akie , Inoue Takanobu , Matsubara Keiko , Horikawa Reiko , Wakui Keiko , Takano Kyoko , Fukushima Yoshimitsu , Tatematsu Toshi , Mizuno Seiji , Tsubaki Junko , Kure Shigeo , Matsubara Yoichi , Ogata Tsutomu , Nagasaki Keisuke , Fukami Maki , Kagami Masayo

Context: Maternal uniparental disomy for chromosome 20 (UPD(20)mat) resulting in aberrant expression of imprinted transcripts at the GNAS locus is a poorly characterized condition. Only 10 non-mosaic cases have been studied clinically. These patients presented with pre- and post-natal growth failure and feeding difficulties. The phenotype of these cases overlapped with that of Silver-Russell syndrome (SRS) and small for gestational age-short stature (SGA-SS); however, the etio...