hrp0089p1-p003 | Adrenals and HPA Axis P1 | ESPE2018
, Karlsson Leif
, Hirvikoski Tatja
, Nordenstrom Anna
, Lajic Svetlana
Background: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is one of the most common autosomal recessive disorders, affecting around 1/10 000 newborns worldwide. Postnatally, patients with classic CAH are treated with life-long glucocorticoid (GC) replacement therapy, such as hydrocortisone or prednisolone, and in the more severe cases also with mineralocorticoids. A negative impact of GCs on human cognition such as memory deficits have been reported bot...