hrp0089p1-p146 | GH & IGFs P1 | ESPE2018

Laron Syndrome Patients have an Abnormal Plasma Amino Acid Pattern

Laron Zvi , Barazani Chen

Background: Laron syndrome (LS), (OMIM#262500) is a rare recessively inherited disease caused by deletions or mutations of the GH receptor, and is characterized by low or undetectable serum IGF-I. This deficiency leads to a series of metabolic abnormalities including of the proteins.Subjects & Method: This study presents for the first time the amino-acid analysis of two untreated and one IGF-I treated LS patients using the LC-MS/MS method (Waters TQS...

hrp0086p2-p667 | Growth P2 | ESPE2016

Birth Length, Weight and Head Circumference of Neonates with IGF-I Receptor Mutations

Essakow Jenna , Lauterpacht Aaron , Laron Zvi

Background: In recent years more and more genetic defects along the GHRH–GH–IGF-I axis have been reported. Those mutations of the IGF-I receptor (R) are a rare abnormality of whom only the heterozygotes progenies survive.Objective and hypotheses: To determine the birth length, weight and brain size using head circumference and find out whether these correlate with the type of mutation.Method: Collection of data of 65 neon...

hrp0082p1-d2-149 | Growth (1) | ESPE2014

Early Development, Growth and Puberty before and During Treatment of Congenital IGHD

Samuel Keren , Kauli Rivka , Laron Zvi

Background: Congenital isolated GH deficiency (cIGHD) is a rare genetic disease occurring mostly in consanguineous families. It is caused by hGH-1 gene deletion or GHRH – receptor mutations.Aim of study: To collect retrospectively size at birth, developmental mile stones, linear and head growth and pubertal development before and during hGH treatment.Subjects: The medical charts of 37/41 patients with cIGHD (21 m, 16 f) contai...

hrp0084p1-101 | Perinatal | ESPE2015

Does Type 1 Childhood Diabetes Start In Utero?

Laron Zvi , Hampe Christiane , Shulman Lester

Background: In the last decades a rapid increase in the incidence of childhood type I diabetes (TIDM) has been reported worldwide. To stop the progressively advancing process immunosuppressive and nutritional trials have been made, but failed. Epidemiological studies by our group performed in several countries have shown that the season during which children who developed TIDM were born differed from that in the general population; suggesting that the initial trigger for TIDM ...

hrp0084p3-950 | GH & IGF | ESPE2015

Growth, Development and Puberty of Patients with Congenital Multiple Pituitary Hormone Deficiencies

Haim-Pinhas Hadar , Kauli Rivka , Laron Zvi

Background: The congenital form of congenital multiple pituitary hormone deficiencies (cMPHD) is rarely differentiated from the acquired type. cMPHD is due to impaired production of several pituitary hormones, caused by mutations in the pituitary transcription factors genes: PROP1, POU1F1 (PIT1), HESX1, LHX3, LHX4. It includes short stature, delayed puberty, cognitive impairment, obesity and metabolic abnormalities.Objective and hypotheses: To evaluate i...

hrp0092p3-273 | Late Breaking Abstracts | ESPE2019

Insulin Sensitivity as Homa at Start and End of HGH Treatment of Children with Congenital (C) Ighd and Mphd

Laron Zvi , Shmalia Mona , Kauli Rivka , Lilos Pnina

Background: Patients with congenital IGHD or MPHD develop adiposity already "in utero". The effects of growth hormone (GH) treatment on adipose tissue are controversial, many claiming that GH reduces body fat (1.2). In addition there are reports that long-term GH treatment causes glucose intolerance, insulin resistance, followed in some instances by diabetes (3).Objective: To determine whether long-term hGH treat...

hrp0089p2-p223 | GH & IGFs P2 | ESPE2018

Health Lifestyle and Obesity of Adult Patients with Congenital Isolated Growth Hormone Deficiency Treated in Childhood

Nun-Yaari Efrat Ben , Kauli Rivka , Lilos Pearl , Laron Zvi

Background: Data on congenital isolated growth hormone deficiency (cIGHD), mostly due to consanguinity, treated in childhood and followed into adult age is very rare and on few patients.Aim: To assess the clinical and social characteristics of adults with cIGHD who were treated in childhood and followed thereafter.Subjects: Thirty nine patients with cIGHD from our clinic were followed into adult age (mean age 30.7±13.3). All w...

hrp0089p3-p397 | Thyroid P3 | ESPE2018

Head Circumference, Birth Length, and Weight of Neonates of Mothers with Hypothyroidism

Laron-Kenet Tamar , Silbergeld Aviva , Lilos Pearl , Laron Zvi

Background: The number of publication on head size of newborns of hypothyroid mothers is scant.Aim: To study concomitantly head circumference, birth length and weight in such neonates.Method: Data was retrieved from computerized medical records of our hospital.Results: One hundred and thirty nine neonates (82 males and 57 females) from a total of 18,538 deliveries at the Rabin Medical Center during the years ...

hrp0094p2-123 | Diabetes and insulin | ESPE2021

Use of the whole country insulin consumption data in Israel showed a reduced prevalence of type 1 diabetes in children aged <5 years during universal Rotavirus vaccination

Laron Zvi , Blumenfeld Orit , Lawrence Gabriella , Shulman Lester ,

Background: Recent studies showed that Rotavirus vaccination may affect the prevalence of type 1 diabetes (T1D). Our aim is to determine the prevalence of early childhood (<5 years) T1D before and during the introduction of Rotavirus vaccination in Israel by syndromic surveillance.Methods: Data on insulin purchases reported by Israel’s four health care organizations (HMOs) was retrieved from the National Program...

hrp0095p1-357 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

The Prolactin (PRL) – Growth Hormone (GH) Relationship during Growth Hormone Stimulation Tests

Laron Zvi , Silbergeld Avivah , Barazani Chen , Lilos Pearl

Background: Despite many similarities between the structure, receptors and proliferative and growth promoting actions, the interrelationship between PRL and GH in clinical conditions has received little attention.Aim: To determine the PRL response to GH stimulation tests.Subjects: Prepubertal and early pubertal boys (n=581) and girls (n=502) with short stature.</p...