ESPE Abstracts

Paternally inherited mutations in the DLK1 (delta-like non-canonical Notch ligand 1) gene cause central precocious puberty (CPP) with a metabolic phenotype, suggesting that DLK1 (Delta-like 1 homolog/Preadipocyte factor 1) may link pubertal timing with body composition. However, little is known about circulating DKL1 in normal and precocious puberty.Objective: To evaluate longitudinal changes in circulating DLK1 concentrations i...

Background: Growth in infancy is considered primarily to be regulated by nutrition and insulin, whereas less is known about the influence of IGF-I, reproductive hormones and other factors of importance. Recently, paternally inherited genetic defects of DLK1 (Delta-like 1 homolog) were found in girls with central precocious puberty (CPP) with a metabolic phenotype. In addition, low maternal serum DLK1 concentrations were significantly lower in pregnant women wh...

Introduction: Management of children with adrenal disorders such as congenital adrenal hyperplasia involves thorough clinical monitoring, including measurements of plasma renin concentrations (PRC) and ACTH. However, sex- and age-related reference intervals (RIs) for PRC and ACTH using novel immunoassays are needed.Aim: To evaluate circulating concentrations of renin and ACTH in children and adolescents from the general ...

Introduction: The pubertal transition is accompanied by voice break in boys. Studies asking men to retrospectively recall their age at voice break report an average age of voice break corresponding to 13.4-14.0 years. However, it may be difficult to remember precisely when your voice broke, and recall bias is quite large. Little is known about voice frequency in boys and girls in relation to pubertal timing.Aim: To asses...