hrp0095p1-378 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Assessment Of External Genitalia Change Over Time In Boys With XY Disorder Of Sex Development (DSD)

Alimussina Malika , Kraria Loubna , McGowan Ruth , Steven Mairi , Lee Boma , Flett Martyn , O’Toole Stuart , Faisal Ahmed S

Introduction: The external masculinisation score (EMS) has been utilised as an objective numerical description of the external genitalia in undermasculinised patients with DSD in several studies. However, data on longitudinal change in EMS in the routine clinical setting are lacking.Objectives: To determine the longitudinal change in EMS and its determinants in a cohort of boys with XY DSD in one specialist centre.<p...

hrp0089p1-p228 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

Clinical Factors that Determine Surgical Outcome Following Hypospadias Repair

Aljuraibah Fahad , Lucas-Herald Angela , Nixon Rachael , Flett Martyn , Lee Boma , Steven Mairi , O'Toole Stuart , Ahmed Faisal

Background: Complication rates following hypospadias surgery are variable and given that hypospadias may be associated with a genetic or an endocrine condition, hypospadias outcome may depend on several clinical factors that require exploration.Aim: To perform a systematic review of cases of hypospadias operated at one tertiary centre to identify clinical determinants of optimal outcome.Methods: Retrospective review of clinical rec...

hrp0097fc7.3 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2023

ROS scavengers may improve genital skin healing in boys with hypospadias

K Lucas-Herald Angela , Hussain Samra , McGinley Kirsty , O'Toole Stuart , Flett Martyn , Steven Mairi , Lee Boma , Basith Amjad S , Faisal Ahmed S

Introduction: Hypospadias is often associated with reduced testosterone synthesis or action. High rates of complications are reported with surgical repair of hypospadias, including wound dehiscence. Boys with hypospadias have previously been demonstrated to have increased reactive oxygen species (ROS) compared to healthy controls and there is a known link between male hypogonadism and oxidative stress. It is not clear what effect ROS has on wound healing in bo...

hrp0089p1-p231 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

Altered Vascular Function in Boys with Hypospadias – Role of Reactive Oxygen Species

Lucas-Herald Angela K , Alves-Lopes Rheure , Haddow Laura , O'Toole Stuart , Basith Amjad S , Flett Martyn , Steven Mairi , Lee Boma , Montezano Augusto C , Faisal Ahmed Syed , Touyz Rhian M.

Background: Hypospadias in boys may be associated with a lack of androgen exposure during the masculinisation programming window. As testosterone has effects on the vasculature, we assessed whether boys with hypospadias show any evidence of vascular dysfunction.Methods: Excess foreskin tissue was obtained from boys undergoing hypospadias repair (cases) or circumcision (controls) and small arteries dissected from this tissue. Vascular contractility was as...

hrp0094p2-397 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2021

Vascular dysfunction and increased cardiovascular risk in hypospadias

Lucas-Herald Angela K , C Montezano Augusto , Alves-Lopes Rheure , Haddow Laura , Alimussina Malika , O’Toole Stuart , Flett Martyn , Lee Boma , Basith Amjad S , Steven Mairi , Brooksbank Katriona , McCallum Linsay , Delles Christian , Padmanabhan Sandosh , Faisal Ahmed S , Touyz Rhian ,

Background: Hypogonadism has been associated with cardiovascular disease. However, little is known about the cardiovascular impact of hypogonadism during development. Using hypospadias as a surrogate of hypogonadism, we investigated whether hypospadias is associated with vascular dysfunction during childhood and whether it is a risk factor for adult cardiovascular disease.Methods: Our human study spanned molecular mechan...