hrp0089p1-p123 | Fat, Metabolism and Obesity P1 | ESPE2018

Interleukin-6 Levels are Associated with High Blood Pressure and Low HDL Cholesterol in Healthy 4-year-old Children

Jung Haewoon , Ah Lee Young , Lee Hye Jin , Lim Youn-Hee , Hong Yun-Chul , Shin Choong Ho , Yang Sei Won

Background: Interleukin-6 (IL-6) is a proinflammatory cytokine associated with obesity, insulin resistance, hypertension, and atherosclerosis in adulthood. Few studies have been conducted in healthy young children. We aimed to investigate whether IL-6 levels are associated with cardiometabolic risk factors in healthy 4-year-old children.Methods: From a prospective cohort study named Environment and Development of Children (EDC) cohort, a total of 421 sin...

hrp0089p1-p243 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology P1 | ESPE2018

Circulating Makorin Ring Finger Protein 3 Levels Predict Central Precocious Puberty in Girls

Jeong Hwal Rim , Lee Hye Jin , Shim Yeong Suk , Kang Min Jae , Yang Seung , Hwang Il Tae

Background/aim: Puberty is a mysterious process about which much is as yet unknown. MKRN3 is involved in regulating the initiation of puberty by inhibiting gonadotropin releasing hormone (GnRH) secretion. This study evaluated the serum level of MKRN3 and investigated its diagnostic usefulness in girls with central precocious puberty (CPP). Changes in the MKRN3 concentration during GnRH agonist (GnRHa) treatment were also analyzed.Methods: In total, 41 gi...