hrp0086s8.2 | Stem cells in endocrine organs | ESPE2016

Pluripotent Stem Cells in Endocrinology

Leibel Rudolph L.

The ability to differentiate human embryonal stem cells (hESC) and induced pluripotent stem cells (hiPSC) into virtually any cell type has enabled the creation of cellular models of diseases for which human cells are not readily accessible. Using these strategies, we have examined the molecular pathogenesis of monogenic forms of diabetes such as WolframÂ’s syndrome and various MODYs using stem cell-derived insulin producing cells created from fibroblasts of patients with t...