hrp0092p3-218 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Clinical Observation of Oral Testosterone Undecanoate Treatmentforchildren with 5-Alpha-Reductase Deficiency

Liu Ying , Gong Chunxiu

Objective: Clinical Observation of fifty-two patients with 5-alpha-reductase deficiency (5 - alpha-reductasedeficiency, 5α-RD) with oral testosterone undecanoate. To evaluate the efficacy and drug safety, find the optimum age of medication.Methods: Prospective self-controlled comparison methods were used to analyze the clinical data and follow-up results in sixty-nine patients who are diagnosed with 5-alpha-reductas...

hrp0089rfc10.2 | Late Breaking | ESPE2018

Non-Inferiority Clinical Trial on Gonadotropinversus Pulsatile Gonadotropin-Releasing Hormone Infusion Therapy in Male Adolescent Patient Withcongenital Hypogonadotropic Hypogonadism

Liu Ying , Gong Chunxiu

Context: We investigate the efficacy and safetyof non-inferiority clinical trial for human chorionic gonadotropin/ human menopaousal gonadotropin (HCG/HMG) versus pulsatile gonadotropin-releasing hormone (GnRH) which have not been evaluated in puberty boys with CHH.Objective: To compare the efficacy and security of two different treatments in male adolescent patient with congenital hypogonadotropic hypogonadism (CHH).Methods: For t...

hrp0084p2-524 | Puberty | ESPE2015

Pulsatile GnRH is Superior to hCG in Therapeutic Efficacy in Adolescent Boys with Hypogonadotropic Hypogonadodism

Gong Chunxiu , Liu Ying , Qin Miao , Wu Di , Wang Xiaoling

Background: We investigate the efficacy and safety of two different treatments which have not been evaluated in peri-puberty boys with HH.Objective and hypotheses: To assess the effectiveness and safety of pulsatile GnRH or hCG treatment in adolescent boys with hypogonadotropic hypogonadodism.Method: 12 patients received 8–10 μg of GnRH, subcutaneously injected every 90 min using a pump. Another 22 patients received hCG, ...

hrp0097fc5.4 | Diabetes and insulin 1 | ESPE2023

Changes of intestinal flora in children with type 1 diabetes mellitus and its related immune mechanism

Liu Ying , Li Liman , Wu Jin , Li Hong

Key words: Type 1 diabetes mellitus; Intestinal flora; metagenomic sequencing; cytokines; AutoimmunityObjective: This study aims to verify the effect of intestinal microbiota diversity on the disease development of T1DM mice model, and to explore the mechanism of intestinal microbiota in the development of type 1 diabetes mediated by related cytokines.Method: T1DM mouse model was e...

hrp0084p2-248 | Diabetes | ESPE2015

Genetic Analysis and Follow-Up of 23 Neonatal Diabetes Mellitus Patients in China

Bingyan Cao , Chunxiu Gong , Di Wu , Chaoxia Lu , Fang Liu , Xiaojing Liu , Ying-xian Zhang , Yi Gu , Zhan Qi , Xiaoqiao Li , Min Liu , Wenjing Li , Chang Su , Xuejun Liang , Mei Feng

Objective: To study the clinical features and gene mutations of neonatal diabetes mellitus (NDM) in Chinese patients.Methods: Patients with clinically diagnosed NDM were subjected to genetic screening by targeted gene capture of the genes associated with glucose metabolism, and followed up.Results: Of the 23 cases of NDM studied, 16 (69.6%) were permanent neonatal diabetes mellitus (PNDM), 6 (26.1%) were transient neonatal diabetes...