hrp0092p3-218 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology | ESPE2019

Clinical Observation of Oral Testosterone Undecanoate Treatmentforchildren with 5-Alpha-Reductase Deficiency

Liu Ying , Gong Chunxiu

Objective: Clinical Observation of fifty-two patients with 5-alpha-reductase deficiency (5 - alpha-reductasedeficiency, 5α-RD) with oral testosterone undecanoate. To evaluate the efficacy and drug safety, find the optimum age of medication.Methods: Prospective self-controlled comparison methods were used to analyze the clinical data and follow-up results in sixty-nine patients who are diagnosed with 5-alpha-reductas...

hrp0089rfc10.2 | Late Breaking | ESPE2018

Non-Inferiority Clinical Trial on Gonadotropinversus Pulsatile Gonadotropin-Releasing Hormone Infusion Therapy in Male Adolescent Patient Withcongenital Hypogonadotropic Hypogonadism

Liu Ying , Gong Chunxiu

Context: We investigate the efficacy and safetyof non-inferiority clinical trial for human chorionic gonadotropin/ human menopaousal gonadotropin (HCG/HMG) versus pulsatile gonadotropin-releasing hormone (GnRH) which have not been evaluated in puberty boys with CHH.Objective: To compare the efficacy and security of two different treatments in male adolescent patient with congenital hypogonadotropic hypogonadism (CHH).Methods: For t...

hrp0084p2-524 | Puberty | ESPE2015

Pulsatile GnRH is Superior to hCG in Therapeutic Efficacy in Adolescent Boys with Hypogonadotropic Hypogonadodism

Gong Chunxiu , Liu Ying , Qin Miao , Wu Di , Wang Xiaoling

Background: We investigate the efficacy and safety of two different treatments which have not been evaluated in peri-puberty boys with HH.Objective and hypotheses: To assess the effectiveness and safety of pulsatile GnRH or hCG treatment in adolescent boys with hypogonadotropic hypogonadodism.Method: 12 patients received 8–10 μg of GnRH, subcutaneously injected every 90 min using a pump. Another 22 patients received hCG, ...

hrp0084p2-248 | Diabetes | ESPE2015

Genetic Analysis and Follow-Up of 23 Neonatal Diabetes Mellitus Patients in China

Bingyan Cao , Chunxiu Gong , Di Wu , Chaoxia Lu , Fang Liu , Xiaojing Liu , Ying-xian Zhang , Yi Gu , Zhan Qi , Xiaoqiao Li , Min Liu , Wenjing Li , Chang Su , Xuejun Liang , Mei Feng

Objective: To study the clinical features and gene mutations of neonatal diabetes mellitus (NDM) in Chinese patients.Methods: Patients with clinically diagnosed NDM were subjected to genetic screening by targeted gene capture of the genes associated with glucose metabolism, and followed up.Results: Of the 23 cases of NDM studied, 16 (69.6%) were permanent neonatal diabetes mellitus (PNDM), 6 (26.1%) were transient neonatal diabetes...